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1

Human Endogenous Retroviruses and Their Putative Role in the Development of Autoimmune Disorders Such as Multiple Sclerosis

Gröger, Victoria, Cynis, Holger

Journal:

Frontiers in Microbiology

Year:

2018

Language:

english

File:

PDF, 418 KB

english, 2018

2

Kallikrein-related peptidases are activators of the CC chemokine CCL14

Grünberg, Mario, Quandt, Dagmar, Cynis, Holger, Demuth, Hans-Ulrich, Kinderman, Andrea, Magdolen, Viktor, Forssmann, Wolf-Georg, Seliger, Barbara, Mägert, Hans-Jürgen

Journal:

European Journal of Immunology

Year:

2018

Language:

english

File:

PDF, 704 KB

english, 2018

3

The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions

Holger Cynis, Torsten Hoffmann, Daniel Friedrich, Astrid Kehlen, Kathrin Gans, Martin Kleinschmidt, Jens-Ulrich Rahfeld, Raik Wolf, Michael Wermann, Anett Stephan, Monique Haegele, Reinhard Sedlmeier,

Journal:

EMBO Molecular Medicine

Year:

2011

Language:

english

File:

PDF, 3.21 MB

english, 2011

4

Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells

Holger Cynis, Stephan Schilling, Mandy Bodnár, Torsten Hoffmann, Ulrich Heiser, Takaomi C. Saido, Hans-Ulrich Demuth

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2006

Language:

english

File:

PDF, 377 KB

english, 2006

5

Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

Oliver Wirths, Henning Breyhan, Holger Cynis, Stephan Schilling, Hans-Ulrich Demuth, Thomas A. Bayer

Journal:

Acta Neuropathologica

Year:

2009

Language:

english

File:

PDF, 568 KB

english, 2009

6

Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms

Maike Hartlage-Rübsamen, Markus Morawski, Alexander Waniek, Carsten Jäger, Ulrike Zeitschel, Birgit Koch, Holger Cynis, Stephan Schilling, Reinhard Schliebs, Hans-Ulrich Demuth, Steffen Roßner

Journal:

Acta Neuropathologica

Year:

2011

Language:

english

File:

PDF, 3.21 MB

english, 2011

7

Inhibition of glutaminyl cyclase prevents pGlu-Aβ formation after intracortical/hippocampal microinjection in vivo/in situ

Stephan Schilling, Thomas Appl, Torsten Hoffmann, Holger Cynis, Katrin Schulz, Wolfgang Jagla, Daniel Friedrich, Michael Wermann, Mirko Buchholz, Ulrich Heiser, Stephan Von Hörsten, Hans-Ulrich Demut

Journal:

Journal of Neurochemistry

Year:

2008

Language:

english

File:

PDF, 1.11 MB

english, 2008

8

Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics

Anett Stephan, Michael Wermann, Alex von Bohlen, Birgit Koch, Holger Cynis, Hans-Ulrich Demuth, Stephan Schilling

Journal:

Year:

2009

Language:

english

File:

PDF, 1.43 MB

english, 2009

9

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β

Nussbaum, Justin M., Schilling, Stephan, Cynis, Holger, Silva, Antonia, Swanson, Eric, Wangsanut, Tanaporn, Tayler, Kaycie, Wiltgen, Brian, Hatami, Asa, Rönicke, Raik, Reymann, Klaus, Hutter-Paier, Bi

Journal:

Year:

2012

Language:

english

File:

PDF, 1.24 MB

english, 2012

10

Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain

Maike Hartlage-Rübsamen, Katharina Staffa, Alexander Waniek, Michael Wermann, Torsten Hoffmann, Holger Cynis, Stephan Schilling, Hans-Ulrich Demuth, Steffen Roßner

Journal:

International Journal of Developmental Neuroscience

Year:

2009

Language:

english

File:

PDF, 4.96 MB

english, 2009

11

Isolation of an Isoenzyme of Human Glutaminyl Cyclase: Retention in the Golgi Complex Suggests Involvement in the Protein Maturation Machinery

Holger Cynis, Jens-Ulrich Rahfeld, Anett Stephan, Astrid Kehlen, Birgit Koch, Michael Wermann, Hans-Ulrich Demuth, Stephan Schilling

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 2.32 MB

english, 2008

12

14 Inhibition of glutaminyl cyclase targeting neurodegeneration and neuroinflammation in Alzheimer's disease

Hans-Ulrich Demuth, S. Schilling, H. Cynis, U. Heiser, S. Manhart, S. Graubner, A. Alexandru, W. Jagla, I. Lues, F. Weber, K. Glund

Journal:

Neurobiology of Aging

Year:

2012

Language:

english

File:

PDF, 60 KB

english, 2012

13

O3-05-07: Inhibition of pyroglutamated amyloid generation: A potential new causative treatment of sporadic Alzheimer's disease

Hans-Ulrich Demuth, Cynis Holger, Stephan Schilling

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 73 KB

english, 2008

14

Amyloidosis and inflammation: Indications for a dual function of glutaminyl cylcase in Alzheimer's disease

Journal:

Alzheimer's & Dementia

Year:

2009

Language:

english

File:

PDF, 65 KB

english, 2009

15

Distinct role of Glutaminyl Cyclases (QCs) in inflammation/neuroinflammation: First results from QC and isoQC knock out mice

Holger Cynis, Sigrid Graubner, Anca Alexandru, Kathrin Gans, Stephan Schilling, Hans-Ulrich Demuth

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 43 KB

english, 2010

16

Inhibition of glutaminyl cyclase targeting Alzheimer's disease

Hans Demuth, Stephan Schilling, Cynis Holger, Susanne Manhart, Konrad Glund

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 57 KB

english, 2012

17

Aβ(pE3-42) potently stimulates CCL2 (MCP-1) secretion

Rico Eichentopf, Stephan Schilling, Cynis Holger, Hans-Ulrich Demuth

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 51 KB

english, 2012

18

Abstract: P642 INHIBITION OF GLUTAMINYL CYCLASE ENHANCES INACTIVATION OF CCL2: A POTENTIAL THERAPY FOR CARDIOVASCULAR DISEASE

Cynis, H, Hoffmann, T, Schilling, S, Demuth, H-U

Journal:

Atherosclerosis Supplements

Year:

2009

Language:

english

File:

PDF, 81 KB

english, 2009

19

Abstract: P689 ISOLATION OF AN ISOENZYME OF HUMAN GLUTAMINYL CYCLASE

Schilling, S, Cynis, H, Demuth, H-U

Journal:

Atherosclerosis Supplements

Year:

2009

Language:

english

File:

PDF, 67 KB

english, 2009

20

N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation

Dagmar Schlenzig, Raik Rönicke, Holger Cynis, Hans-Henning Ludwig, Eike Scheel, Klaus Reymann, Takaomi Saido, Gerd Hause, Stephan Schilling, Hans-Ulrich Demuth

Journal:

Journal of Neurochemistry

Year:

2012

Language:

english

File:

PDF, 713 KB

english, 2012

21

A quantitative analysis of spontaneous isoaspartate formation from N-terminal asparaginyl and aspartyl residues

Bert H.-O. Güttler, Holger Cynis, Franziska Seifert, Hans-Henning Ludwig…

Journal:

Year:

2013

Language:

english

File:

PDF, 304 KB

english, 2013

22

Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration

Becker, Andreas, Kohlmann, Stephanie, Alexandru, Anca, Jagla, Wolfgang, Canneva, Fabio, Bäuscher, Christoph, Cynis, Holger, Sedlmeier, Reinhard, Graubner, Sigrid, Schilling, Stephan, Demuth, Hans-Ulri

Journal:

BMC Neuroscience

Year:

2013

Language:

english

File:

PDF, 1.85 MB

english, 2013

23

N-terminal pyroglutamate (pGlu) formation enhances Aß oligomer formation and potency to disrupt hippocampal LTP

Schilling, Stephan, Schlenzig, Dagmar, Rönicke, Raik, Holger, Cynis, Reymann, Klaus, Saido, Takaomi, Demuth, Hans-Ulrich

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 56 KB

english, 2012

24

Inhibition of Glutaminyl Cyclase: Pharmacology and steps towards clinical development

Demuth, Hans-Ulrich, Cynis, Holger, Alexandru, Anca, Jagla, Wolfgang, Graubner, Sigrid, Stephan v. Hoersten,, Schilling, Stephan

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 222 KB

english, 2010

25

Pyroglutamate-3 Amyloid-β Deposition in the Brains of Humans, Non-Human Primates, Canines, and Alzheimer Disease–Like Transgenic Mouse Models

Frost, Jeffrey L., Le, Kevin X., Cynis, Holger, Ekpo, Elizabeth, Kleinschmidt, Martin, Palmour, Roberta M., Ervin, Frank R., Snigdha, Shikha, Cotman, Carl W., Saido, Takaomi C., Vassar, Robert J., Geo

Journal:

The American Journal of Pathology

Year:

2013

Language:

english

File:

PDF, 2.03 MB

english, 2013

26

N-terminal truncation and pyroglutamate modification of amyloid peptides: Potential strategies to interfere with neurodegenerative pathogenesis in Alzheimer's disease, FBD, FDD

Schilling, Stephan, Cynis, Holger, Rönicke, Raik, Reymann, Klaus, Seifert, Franziska, Schlenzig, Dagmar, Demuth, Hans-Ulrich

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 67 KB

english, 2010

27

Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC

Höfling, Corinna, Indrischek, Henrike, Höpcke, Theodor, Waniek, Alexander, Cynis, Holger, Koch, Birgit, Schilling, Stephan, Morawski, Markus, Demuth, Hans-Ulrich, Roßner, Steffen, Hartlage-Rübsamen, M

Journal:

International Journal of Developmental Neuroscience

Year:

2014

Language:

english

File:

PDF, 2.29 MB

english, 2014

28

Annual Summer Fiction Double Issue || Self-Portrait as Janis Joplin

Journal:

The North American Review

Year:

2003

Language:

english

File:

PDF, 214 KB

english, 2003

29

Glutaminyl Cyclase Knock-out Mice Exhibit Slight Hypothyroidism but No Hypogonadism: IMPLICATIONS FOR ENZYME FUNCTION AND DRUG DEVELOPMENT

Schilling, S., Kohlmann, S., Bauscher, C., Sedlmeier, R., Koch, B., Eichentopf, R., Becker, A., Cynis, H., Hoffmann, T., Berg, S., Freyse, E.-J., von Horsten, S., Rossner, S., Graubner, S., Demuth, H.

Journal:

Journal of Biological Chemistry

Year:

2011

Language:

english

File:

PDF, 1.94 MB

english, 2011

30

Amyloidogenic Processing of Amyloid Precursor Protein: Evidence of a Pivotal Role of Glutaminyl Cyclase in Generation of Pyroglutamate-Modified Amyloid-β †

Cynis, Holger, Scheel, Eike, Saido, Takaomi C., Schilling, Stephan, Demuth, Hans-Ulrich

Journal:

Year:

2008

Language:

english

File:

PDF, 3.44 MB

english, 2008

31

Isolation, Catalytic Properties, and Competitive Inhibitors of the Zinc-Dependent Murine Glutaminyl Cyclase †

Schilling, Stephan, Cynis, Holger, von Bohlen, Alex, Hoffmann, Torsten, Wermann, Michael, Heiser, Ulrich, Buchholz, Mirko, Zunkel, Katrin, Demuth, Hans-Ulrich

Journal:

Year:

2005

Language:

english

File:

PDF, 232 KB

english, 2005

32

Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice

Cynis, Holger, Kehlen, Astrid, Haegele, Monique, Hoffmann, Torsten, Heiser, Ulrich, Fujii, Masato, Shibazaki, Yuichiro, Yoneyama, Hiroyuki, Schilling, Stephan, Demuth, Hans-Ulrich

Journal:

International Journal of Experimental Pathology

Year:

2013

Language:

english

File:

PDF, 712 KB

english, 2013

33

Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer’s disease

Hartlage-Rübsamen, Maike, Waniek, Alexander, Meißner, Juliane, Morawski, Markus, Schilling, Stephan, Jäger, Carsten, Kleinschmidt, Martin, Cynis, Holger, Kehlen, Astrid, Arendt, Thomas, Demuth, Hans-U

Journal:

Acta Neuropathologica

Year:

2015

Language:

english

File:

PDF, 15.08 MB

english, 2015

34

Glutaminyl Cyclases as Novel Targets for the Treatment of Septic Arthritis

Hellvard, A., Maresz, K., Schilling, S., Graubner, S., Heiser, U., Jonsson, R., Cynis, H., Demuth, H.-U., Potempa, J., Mydel, P.

Journal:

The Journal of Infectious Diseases

Year:

2013

Language:

english

File:

PDF, 429 KB

english, 2013

35

Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated A Is Induced by Pyroglutamate-A Formation

Alexandru, A., Jagla, W., Graubner, S., Becker, A., Bauscher, C., Kohlmann, S., Sedlmeier, R., Raber, K. A., Cynis, H., Ronicke, R., Reymann, K. G., Petrasch-Parwez, E., Hartlage-Rubsamen, M., Waniek,

Journal:

Journal of Neuroscience

Year:

2011

Language:

english

File:

PDF, 6.63 MB

english, 2011

36

IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes

Becker, Andreas, Eichentopf, Rico, Sedlmeier, Reinhard, Waniek, Alexander, Cynis, Holger, Koch, Birgit, Stephan, Anett, Bäuscher, Christoph, Kohlmann, Stephanie, Hoffmann, Torsten, Kehlen, Astrid, Ber

Journal:

Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 1.13 MB

english, 2016

37

Upper Peninsula Woods, September 1971

Journal:

Year:

2009

Language:

english

File:

PDF, 242 KB

english, 2009

38

Handbook of Biologically Active Peptides || Glutaminyl Cyclases

Year:

2013

Language:

english

File:

PDF, 599 KB

english, 2013

39

EVIDENCE FOR INVOLVEMENT OF MEPRIN B IN FORMATION OF N-TRUNCATED AND PYROGLUTAMATE -MODIFIED (PGLU) ABETA

Schilling, Stephan, Schlenzig, Dagmar, Cynis, Holger, Demuth, Hans-Ulrich

Journal:

Alzheimer's & Dementia

Year:

2014

Language:

english

File:

PDF, 50 KB

english, 2014

40

ALTERNATIVE BETA-SECRETASE PROCESSING GENERATES N-TERMINALLY TRUNCATED ABETA PEPTIDES IN MAMMALIAN CELLS

Cynis, Holger, Schlenzig, Dagmar, Zeitschel, Ulrike, Hartlage-Rübsamen, Maike, Roßner, Steffen, Schilling, Stephan, Demuth, Hans-Ulrich

Journal:

Alzheimer's & Dementia

Year:

2014

Language:

english

File:

PDF, 75 KB

english, 2014

41

Immunotherapy targeting pyroglutamate-3 Aβ: prospects and challenges

Cynis, Holger, Frost, Jeffrey L., Crehan, Helen, Lemere, Cynthia A.

Journal:

Molecular Neurodegeneration

Year:

2016

Language:

english

File:

PDF, 709 KB

english, 2016

42

MEPRIN β IS ASSOCIATED WITH FORMATION OF PYROGLUTAMATE-MODIFIED Aβ PEPTIDES

Schilling, Stephan, Schlenzig, Dagmar, Cynis, Holger, Hartlage-Rübsamen, Maike, Rossner, Steffen, Demuth, Hans-Ulrich

Journal:

Alzheimer's & Dementia

Year:

2016

Language:

english

File:

PDF, 67 KB

english, 2016

43

Pyroglutamate-Amyloid-� and Glutaminyl Cyclase Are Colocalized with Amyloid-� in Secretory Vesicles and Undergo Activity-Dependent, Regulated Secretion

Cynis, Holger, Funkelstein, Lydiane, Toneff, Thomas, Mosier, Charles, Ziegler, Michael, Koch, Birgit, Demuth, Hans-Ulrich, Hook, Vivian

Journal:

Neurodegenerative Diseases

Year:

2014

Language:

english

File:

PDF, 490 KB

english, 2014

44

Structure-guided design, synthesis and characterization of next-generation meprin β inhibitors

Ramsbeck, Daniel, Hamann, Antje, Richter, Georg, Schlenzig, Dagmar, Geissler, Stefanie, Nykiel, Vera, Cynis, Holger, Schilling, Stephan, Buchholz, Mirko

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.14 MB

english, 2018

45

Dipeptidyl-Peptidase Activity of Meprin β Links N-truncation of Aβ with Glutaminyl Cyclase-Catalyzed pGlu-Aβ Formation

Schlenzig, Dagmar, Cynis, Holger, Hartlage-Rübsamen, Maike, Zeitschel, Ulrike, Menge, Katja, Fothe, Anja, Ramsbeck, Daniel, Spahn, Claudia, Wermann, Michael, Roßner, Steffen, Buchholz, Mirko, Schillin

Journal:

Journal of Alzheimer's Disease

Year:

2018

Language:

english

File:

PDF, 997 KB

english, 2018

46

Identification of human endogenous retrovirus transcripts in Hodgkin Lymphoma cells

Barth, Marie, Gröger, Victoria, Cynis, Holger, Staege, Martin Sebastian

Journal:

Molecular Biology Reports

Year:

2019

Language:

english

File:

PDF, 3.37 MB

english, 2019

47

TARGETING ISOASPARTATE-MODIFIED Aβ: A DIFFERENTIAL APPROACH OF PASSIVE IMMUNOTHERAPY

Rahfeld, Jens-Ulrich, Piechotta, Anke, Gnoth, Kathrin, Rossner, Steffen, Nykiel, Vera, Cynis, Holger, Demuth, Hans-Ulrich, Schilling, Stephan

Journal:

Alzheimer's & Dementia

Year:

2018

Language:

english

File:

PDF, 189 KB

english, 2018

48

A NEW MOUSE MODEL WITH HUMANIZED WILD-TYPE TAU EXPRESSION

Cynis, Holger, Barendrecht, Susan, Balschun, Detlef, Schilling, Stephan, Demuth, Hans-Ulrich

Journal:

Alzheimer's & Dementia

Year:

2018

Language:

english

File:

PDF, 122 KB

english, 2018

49

P4-474: CHARACTERIZATION OF A NOVEL HUMANIZED WILD-TYPE TAU EXPRESSING MOUSE MODEL IN HIGH-AMYLOID BACKGROUND OF 5XFAD MICE

Cynis, Holger, Barendrecht, Susan, Geissler, Stefanie, Demuth, Hans-Ulrich, Schilling, Stephan, Schreurs, An, Balschun, Detlef

Journal:

Alzheimer's & Dementia

Year:

2019

File:

PDF, 80 KB

2019

50

Viromers as carriers for mRNA-mediated expression of therapeutic molecules under inflammatory conditions

Jansig, Edith, Geissler, Stefanie, Rieckmann, Vera, Kuenemund, Anja, Hietel, Benjamin, Schenk, Mathias, Wussow, Sebastian, Kreideweiss, Patrick, Panzner, Steffen, Reinsch, Christian, Cynis, Holger

Journal:

Scientific Reports

Year:

2020

File:

PDF, 3.23 MB

2020